I've been fortunate enough to work on a number of high profile projects with Knight Studios over the past few years, so it was my pleasure to build their portfolio website, designed by Knight Studios. And it was quite a challenge.
The design follows a tight grid. Within the CMS you have the option to choose a different layout/structure and colour scheme for every project added, creating an almost totally customisable layout/structure.
HTML5. CSS. jQuery. PHP.